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What is VOQUEZNA? <ul style="text-align:left"> <li>VOQUEZNA® (vonoprazan) is a prescription medicine used in adults: 	<ul> 	<li>for 8 weeks to heal acid-related damage to the lining of the esophagus (called Erosive Esophagitis) and for relief of heartburn related to Erosive Esophagitis.</li></ul>

INDICATION AND IMPORTANT SAFETY INFORMATION

What is VOQUEZNA? <ul style="text-align:left"> <li>VOQUEZNA® (vonoprazan) is a prescription medicine used in adults: 	 <ul> 	 <li>for 8 weeks to heal acid-related damage to the lining of the esophagus (called Erosive Esophagitis) and for relief of heartburn related to Erosive Esophagitis.</li> 	 <li>for up to 6 months to maintain healing of Erosive Esophagitis and for relief of heartburn related to Erosive Esophagitis.</li> <li>for 4 weeks for relief of heartburn related to gastroesophageal reflux disease (GERD).</li>	 </ul> It is not known if VOQUEZNA is safe and effective in children.</li> </ul> Do not take VOQUEZNA if you: <ul style="text-align:left"> <li>are allergic to vonoprazan or any of the other ingredients in VOQUEZNA. Allergic reaction symptoms may include trouble breathing, rash, itching, and swelling of your face, lips, tongue or throat.</li> <li>are taking a medicine that contains rilpivirine (EDURANT, COMPLERA, JULUCA, ODEFSEY) used to treat HIV-1 (Human Immunodeficiency Virus).</li></ul> Before taking VOQUEZNA, tell your healthcare provider about all your medical conditions, including if you: <ul style="text-align:left"> <li>have low magnesium, calcium, or potassium in your blood, or you are taking a medicine to increase urine (diuretic).</li> <li>have kidney or liver problems.</li> <li>are pregnant, think you may be pregnant, or plan to become pregnant. It is not known if VOQUEZNA will harm your unborn baby.</li> <li>are breastfeeding or plan to breastfeed. It is not known if VOQUEZNA passes into your breast milk. You and your healthcare provider should decide if you will take VOQUEZNA or breastfeed. You should not do both.</li> </ul> Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. VOQUEZNA may affect how other medicines work, and other medicines may affect how VOQUEZNA works. Especially tell your healthcare provider if you take medicine that contains rilpivirine (EDURANT, COMPLERA, JULUCA, ODEFSEY). What are the possible side effects of VOQUEZNA? VOQUEZNA may cause serious side effects including: <ul style="text-align:left"> <li>A type of kidney problem (acute tubulointerstitial nephritis): Some people who take VOQUEZNA may develop a kidney problem called acute tubulointerstitial nephritis. Call your healthcare provider right away if you have a decrease in the amount that you urinate or if you notice blood in your urine.</li> <li>Diarrhea caused by an infection (Clostridioides difficile) in your intestines: Call your healthcare provider right away if you have watery stools, stomach pain, and fever that does not go away.</li> <li>Bone fractures (hip, wrist, or spine): Bone fractures in the hip, wrist, or spine may happen in people who take multiple daily doses of another type of medicine that reduces acid in your stomach known as proton pump inhibitors (PPI medicines) for a long period of time (a year or longer). Tell your healthcare provider if you have a bone fracture, especially in the hip, wrist, or spine.</li> <li>Severe skin reactions: VOQUEZNA can cause rare, but severe skin reactions that may affect any part of your body. These serious skin reactions may need to be treated in a hospital and may be life threatening: </li> 	 <ul> 	<li>Skin rash which may have blistering, peeling, or bleeding on any part of your skin.</li> 	 <li>You may also have fever, chills, body aches, shortness of breath, or enlarged lymph nodes.</li></ul> If you experience any of these symptoms, stop taking VOQUEZNA and call your healthcare provider right away. These symptoms may be the first sign of a severe skin reaction. <li>Low vitamin B-12 levels: VOQUEZNA lowers the amount of acid in your stomach. Stomach acid is needed to absorb Vitamin B12 properly. Tell your healthcare provider if you have symptoms of low vitamin B12 levels, including irregular heartbeat, shortness of breath, lightheadedness, tingling or numbness in the arms or legs, muscle weakness, pale skin, feeling tired, or mood changes. Talk with your healthcare provider about the risk of low vitamin B12 levels if you have been on VOQUEZNA for a long time.</li> <li>Low magnesium levels in the body can happen in people who take VOQUEZNA. Tell your healthcare provider right away if you have symptoms of low magnesium levels, including seizures, dizziness, irregular heartbeat, jitteriness, muscle aches or weakness, or spasms of hands, feet, or voice.</li> <li>Stomach growths (fundic gland polyps): A certain type of stomach growth called fundic gland polyps may happen in people who take another type of medicine that reduces acid in your stomach known as proton pump inhibitors (PPI medicines) for a long time. Talk with your healthcare provider about the possibility of fundic gland polyps if you have been on VOQUEZNA for a long time.</li> </ul> The most common side effects of VOQUEZNA for treatment of Erosive Esophagitis and/or relief of heartburn related to gastroesophageal reflux disease include: <ul style="text-align:left"> <li>stomach inflammation</li> <li>diarrhea</li> <li>stomach bloating</li> <li>stomach pain</li> <li>nausea</li> <li>indigestion</li> <li>constipation</li> <li>high blood pressure</li> <li>urinary tract infection </li> </ul> These are not all the possible side effects of VOQUEZNA. For more information, ask your healthcare provider or pharmacist. Call your healthcare provider for medical advice about side effects. You are encouraged to report suspected adverse reactions by contacting Phathom Pharmaceuticals at <a href="tel:888-775-7428">1-888-775-PHAT</a> (7428) or FDA at <a href="tel:800-332-1088">1-800-FDA-1088</a> or <a href="https://www.fda.gov/medwatch" target="_blank">www.fda.gov/medwatch</a>. Please see <a href="http://www.phathompharma.com/wp-content/uploads/VOQUEZNA-Patient-Information.pdf" target="_blank">Patient Information</a> and full <a href="http://www.phathompharma.com/wp-content/uploads/VOQUEZNA-tablets-Prescriber-Information.pdf" target="_blank">Prescribing Information</a> for VOQUEZNA.

INDICATION AND IMPORTANT SAFETY INFORMATION

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